Dopamine 是在脑黑质，脑腹侧被盖区和下丘脑中产生的一种儿茶酚胺类神经递质，在大脑和身体中起着重要作用。Dopamine 通过 D2 多巴胺受体 (D2 dopamine receptor) 来诱导 VEGFR2 的内吞作用，这对于促进血管生成是至关重要的。
| 生物活性 |
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis. |
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| 体外研究 |
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 µM; 24hours). Cell Proliferation Assay
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| 体内研究 |
Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF.
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| 分子式 |
C8H11NO2
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| 分子量 |
153.18
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| CAS号 |
51-61-6
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| 中文名称 |
多巴胺
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 科研文献 |
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