FPA-124，一种细胞通透性铜配合物，是选择性的 Akt 抑制剂，IC50 为 0.1 μM ，与 Akt 的蛋白同源性 (PH) 域和激酶结构域相互作用。FPA-124 诱导细胞凋亡 (apoptosis)。
| 生物活性 |
FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis. |
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| 体外研究 |
FPA-124 exhibits dose-dependent growth inhibitory effects with IC50s of 7, 10, 34, and 55 μM in BT20, PC-3, COLO 357 and BxPC-3 cancer cell lines, respectively. |
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| 体内研究 |
FPA-124 exhibits PKB (Akt protein) inhibitory activities and causes NF-κB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells.
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| 分子式 |
C11H9N3O2S.Cl2Cu
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| 分子量 |
381.73
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| CAS号 |
902779-59-3
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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