Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor, induces inflammation in a rodent model of pleurisy, and reduces memory loss induced by Aβ1-42 in a mouse model of Alzheimer's disease.
| 分子式 |
C11H17N5O9P2
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| 分子量 |
425.23
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| CAS号 |
104835-70-3
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| 中文名称 |
Α,Β-亚甲基腺苷 5'-二磷酸钠盐
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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纯度： 98%
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