| 生物活性 |
YSK05 is an ionizable amino lipid (apparent pKa = ~6.5) that has been used in combination with other lipids in the formation of liposomes and lipid nanoparticles (LNPs). Administration of cyclic di-GMP in YSK05-containing liposomes increases serum levels of IFN-β, IFN-γ, IL-6, and TNF-α and activates natural killer (NK) cells in mice, as well as decreases lung metastasis in a B16/F10 murine melanoma model of metastasis. Intravenous administration of factor VII siRNA in YSK05-containing LNPs reduces factor VII activity in isolated mouse plasma.
|
|---|---|
| 分子式 |
C42H77NO2
|
| 分子量 |
628.1
|
| CAS号 |
1318793-78-0
|
| 中文名称 |
YSK 05
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere.
|
| 储存方式 |
Store at -20°C
|
纯度： >90%
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