Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca agonist.
体外研究
Taurolithocholic acid (TLCA) at low concentrations (5 µM) tends to selectively increase the membrane-associated fraction of the e-isoform of PKC by 44.1% ± 40.2%.
TLCA (10 µM) selectively induces translocation of theε-isoform of PKC to the hepatocellular membranes, a key step for activation of mobile PKC isoforms.
体内研究
Taurolithocholic acid (TLCA) exerts cholestatic effects via PI3K-dependent mechanisms in perfused rat Livers and rat hepatocyte couplets.
分子式
C26H44NNaO5S
分子量
505.69
CAS号
6042-32-6
运输条件
Room temperature in continental US; may vary elsewhere.