MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration.
IC50&Target
Ki: 7.9 nM (OGA)
体内研究
MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response.
分子式
C9H14F2N2O3S
分子量
268.28
CAS号
1382799-40-7
运输条件
Room temperature in continental US; may vary elsewhere.