NE 10790 是法尼焦磷酸 (FPP) 合成酶的弱抑制剂，是有效的二磷酸利塞磷酸盐的磷酸酯类似物，也是一种弱的抗吸收剂。
| 生物活性 |
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent. |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究 |
NE 10790 inhibits incorporation of [C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I. |
||||||||||||||||
| 分子式 |
C8H10NO6P
|
||||||||||||||||
| 分子量 |
247.14
|
||||||||||||||||
| CAS号 |
152831-36-2
|
||||||||||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
| 储存方式 |
|
||||||||||||||||
| 溶解性数据 |
In Vitro:
0.1 M NaOH : 20 mg/mL (80.93 mM; ultrasonic and adjust pH to 6 with NaOH) H2O : 5 mg/mL (20.23 mM; ultrasonic and adjust pH to 6 with NaOH) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
纯度： 98%
关注我们
获得KKL MED 最新资讯
咨询热线：
400-881-9290
Data Sheet