Rp-cAMPS sodium salt - CAS:142439-94-9

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Rp-cAMPS sodium salt

目录号 : KM9596 CAS No. : 142439-94-9 纯度 : 98%

Data Sheet 产品使用指南

Rp-cAMPS sodium salt，一种 cAMP 的类似物，是一种 cAMP 诱导的 PKA I 和 PKA II 活化 (K_i 分别为 12.5 µM 和 4.5 µM) 的有效的，竞争性拮抗剂。Rp-cAMPS sodium salt 耐磷酸二酯酶水解。

规格	价格	是否有货
1mg		In-stock
5mg	询价	In-stock
10mg	询价	In-stock
50mg	询价	In-stock

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Ginkgolide K In-stock
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NH-3 In-stock
Velufenacin In-stock

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生物活性

Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases.

体外研究

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.

体内研究

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.

分子量

367.25

CAS号

142439-94-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

H₂O : 250 mg/mL (680.74 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7229 mL	13.6147 mL	27.2294 mL
5 mM	0.5446 mL	2.7229 mL	5.4459 mL
10 mM	0.2723 mL	1.3615 mL	2.7229 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

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