CDK8-IN-1 是一个有效的、CDK8 的选择性抑制剂，其 IC50 值为 3 nM。
| 生物活性 |
CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. |
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| 体内研究 |
CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively.
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| 分子式 |
C11H8F3N3O
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| 分子量 |
255.20
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| CAS号 |
1629633-48-2
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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