tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.
IC50&Target
Notch1
体外研究
tCFA15 (10 nM-1 μM) dose-dependently affects the differentiation of neural stem cell-derived neurospheres by promoting neurons at the expense of astrocytes, and such effect is via Notch1. tCFA15 (1 μM) specifically decreases the level of Notch1 mRNA in spheres, and such an effect is also observed in decreases Notch1 expression in neuronal and glial cell cultures. tCFA15 stimulates arginine vasopressin secretion in nerve terminals of the neurohypophysis.
分子式
C24H44O2
分子量
364.60
CAS号
220757-88-0
运输条件
Room temperature in continental US; may vary elsewhere.