Phosphoramide mustard (cyclohexanamine) - CAS:1566-15-0

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Phosphoramide mustard (cyclohexanamine)

目录号 : KM8497 CAS No. : 1566-15-0 纯度 : ≥95%

Data Sheet 产品使用指南

Phosphoramide mustard cyclohexanamine 是环磷酰胺的活性代谢物，具有抗肿瘤活性。Phosphoramide mustard cyclohexanamine 能诱导 DNA 损伤。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage.

体外研究

Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication.
Phosphoramide mustard cyclohexanamine (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells (SIGCs).
Phosphoramide mustard cyclohexanamine (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage.
Phosphoramide mustard cyclohexanamine (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins.

Cell Viability Assay

Cell Line:	SIGCs
Concentration:	0.5 μM, 1 μM, 3 μM, 6 μM
Incubation Time:	48 hours
Result:	Reduced cell viability at concentrations of 3 μM and higher.

RT-PCR

Cell Line:	SIGCs
Concentration:	3 μM, 6 μM
Incubation Time:	24 hours, 48 hours
Result:	Increased DDR gene mRNA expression levels.

Western Blot Analysis

Cell Line:	SIGCs
Concentration:	3 μM, 6 μM
Incubation Time:	24 hours, 48 hours
Result:	Generally increased DDR proteins.

体内研究

Phosphoramide mustard cyclohexanamine (2.1-20.7 mg/kg; i.p.; daily; for 5 days) inhibits subcutaneous tumor growth in rats.
Phosphoramide mustard cyclohexanamine exhibits terminal elimination half-lives (rat 15.1 min) following intravenous administration (rat 59.4 mg/kg).

Animal Model:	Rat, subcutaneously implanted Walker 256 carcinosarcoma tumor
Dosage:	2.1 mg/kg, 4.8 mg/kg, 10.4 mg/kg, 20.7 mg/kg
Administration:	Intraperitoneal injection, once daily, for 5 consecutive days
Result:	Required to produce 50% inhibition of subcutaneous tumor growth with dose of 12 mg/kg.

Animal Model:	Rats
Dosage:	86.0 mg/kg (Pharmacokinetic Analysis)
Administration:	Intravenous injection
Result:	T_1/2 (15.1 min).

分子式

C₄H₁₁N₂O₂PCl₂^.C₆H₁₃N

分子量

320.20

CAS号

1566-15-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

H₂O : 100 mg/mL (312.30 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1230 mL	15.6152 mL	31.2305 mL
5 mM	0.6246 mL	3.1230 mL	6.2461 mL
10 mM	0.3123 mL	1.5615 mL	3.1230 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%

Data Sheet

产品使用指南

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