EGFR-IN-8 - CAS:2407957-87-1

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EGFR-IN-8

目录号 : KM8325 CAS No. : 2407957-87-1 纯度 : 98%

Data Sheet 产品使用指南

EGFR-IN-8 是 EGFR 和 c-Met 双重抑制剂，化合物 48。EGFR-IN-8 有望成为进一步开发靶向 EGFR TKI 抗性 NSCLC 药物的靶点。

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10mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

EGFR-IN-8 is a dual EGFR and c-Met inhibitor, compound 48. EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC.

体外研究

EGFR-IN-8 (0-20 μM; 24-72 hours) exhibits a time- and dose-dependent inhibitory effect on the viability of A549, PC9, H1975, CL68, and CL97 cells at different time intervals, with IC₅₀ values ranging from 0.3 to 0.6 μM and 0.2-0.5 μM after 48 and 72 h of treatment respectively.
EGFR-IN-8 (0-0.6 μM; 48 hours) suppresses the expression of EGFR and c-Met in these five cell lines irrespective of their mutational status.

Cell Viability Assay

Cell Line:	A549, PC9, H1975, CL68, and CL97 cells
Concentration:	0-20 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Showed inhibitory effects on different cells.

Western Blot Analysis

Cell Line:	A549, PC9, H1975, CL68, and CL97 cells
Concentration:	0-0.6 μM
Incubation Time:	48 hours
Result:	Decreased EGFR and c-Met expression.

体内研究

EGFR-IN-8 (oral gavage; 50 and 150 mg/kg; once daily; 20 days) exhibits a dose-dependent suppression (29% and 60%, respectively) of H1975 xenograft tumor growth at 50 and 150 mg/kg.

Animal Model:	Nude mice H1975 xenograft tumor model
Dosage:	50 and 150 mg/kg
Administration:	Oral gavage; 50 and 150 mg/kg; once daily; 20 days
Result:	Inhibited H1975 xenograft tumor growth.

分子式

C₃₂H₂₃ClF₃N₇O₄

分子量

662.02

CAS号

2407957-87-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 8.33 mg/mL (12.58 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5105 mL	7.5526 mL	15.1053 mL
5 mM	0.3021 mL	1.5105 mL	3.0211 mL
10 mM	0.1511 mL	0.7553 mL	1.5105 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%

Data Sheet

产品使用指南

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稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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