Azoxymethane 是一种结肠致癌物质，可导致 DNA 加合物的形成。
| 生物活性 |
Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts. |
|---|---|
| 体外研究 |
Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts. On an equal protein basis, hepatic microsomes are much more active than SI and colon microsomes in NADPH-dependent Azoxymethane bioactivation and N-mG adduct formation. Hepatic microsomes show the highest activity in the hydroxylation of Azoxymethane, followed by SI and colon microsomes.
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| 体内研究 |
Regardless of the strain, the amounts of O-mG and N-mG produced by Azoxymethane are highest in the liver, followed by proximal and distal colons, which have similar levels, and then by duodenum, jejunum and ileum. Results indicate that the Azoxymethane-induced DNA adduct formation in the SI and colon does not depend on bioactivation by hepatic P450 enzymes. Irrespective of the mouse strain, no aberrant crypt foci (ACF) is detected in the colons of saline-treated mice; in contrast, colonic ACF is detected in all three strains of Azoxymethane-treated mice. The Azoxymethane-treated athymic mice have approximately an 11-fold lower tumor incidence than similarly treated WT animals.
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| 分子式 |
C2H6N2O
|
| 分子量 |
74.08
|
| CAS号 |
25843-45-2
|
| 中文名称 |
偶氮甲烷
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Solution, -20°C, 2 years |
| 临床试验 |
This product can potently induce colon cancer in mice and rats. As a reagent for establishing colon cancer models, it is widely used in the exploration of cancer preventive substances and the research on the mechanism of cancer initiation. As concerns about colon cancer continue to increase, and the search for cancer preventive substances becomes more active, the role this product plays is very important. The average dose of this product was 15 mg/kg (body weight) administered subcutaneously to rats once weekly for approximately 3 weeks, after which abnormal crypt foci (ACF) were detected. Reagents for establishing pathological animal models The use of pathological model animals is one of the important research methods to study various diseases. By administering chemical substances to animals such as rats and mice, pathological animal models that express the characteristics of human diseases can be established. |
| 科研文献 |
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