Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) 是一种合成的 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate)，包含基于 Pomalidomide 的 cereblon 配体和 5 个单元 PEG 的 linker。
| 生物活性 |
Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology. |
|---|---|
| 体外研究 |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| 分子式 |
C26H35N3O11
|
| 分子量 |
565.57
|
| CAS号 |
2139348-63-1
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
纯度： 95%
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