TRC-766 是一种 RTC-5 (TRC-382) 的阴性对照。TRC-766 可结合蛋白磷酸酶 2A (PP2A)，但不激活磷酸酶。
| 生物活性 |
TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase. |
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| 体外研究 |
As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability. |
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| 分子式 |
C25H24ClF3N2O3S
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| 分子量 |
524.98
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| CAS号 |
1810734-44-1
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
DMSO : 150 mg/mL (285.73 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
纯度： 98%
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