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CCT369260
目录号 : KM7922 纯度 : 98%
Data Sheet 产品使用指南

CCT369260 (compound 1) 是具有口服活性的、B 细胞淋巴瘤 6 (BCL6) 抑制剂，具有抗肿瘤活性，其 IC50 值为 520 nM。

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Other Forms of Rapamycin:

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生物活性

CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM.

体内研究

CCT369260 (compound 1, 15 mg/kg, po, single dose) significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model.

Animal Model: OCI-Ly1 DLBCL xenograft model (female SCID mice).
Dosage: 15 mg/kg.
Administration: PO, single dose.
Result: Decreased the levels of BCL6 in the tumor observed up to 10 h after administration.
Animal Model: Female Balb/C mice.
Dosage: 1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis).
Administration: IV and PO
Result: Demonstrated moderate clearance (CL 20 mL min kg) with mean oral bioavailability of 54%.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 300 mg/mL (589.40 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9647 mL 9.8234 mL 19.6468 mL
5 mM 0.3929 mL 1.9647 mL 3.9294 mL
10 mM 0.1965 mL 0.9823 mL 1.9647 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
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