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Thioflosulide (L-745337)
目录号 : KG12592 CAS No. : 158205-05-1 纯度 : 98%
Data Sheet 产品使用指南
Thioflosulide (L-745337) is a selective cyclooxygenase-2 (COX2) inhibitor, with an IC50 of 2.3 nM, and shows anti-inflammatory activity. In a rat model of postoperative pain, Thioflosulide (L-745337) (40-80 μg, intrathecal) coadministered with intrathecal morphine (0.5 nmol) increases the withdrawal thresholds in a dose-dependent manner. Adding 80 μg Thioflosulide (L-745337) to 1 nmol morphine produces an antiallodynic effect greater than that of morphine at twice the dose. Thioflosulide (L-745337) (0-30 mg/kg, s.c.) combined with intrathecal morphine results in the same antiallodynic response as morphine alone. Thioflosulide (L-745337) shows anti-inflammatory activity, with the effective-dose of 0.4 mg/kg, and the maximal anti-inflammation dose of 5 mg/kg in arthritic rats.
规格 价格 是否有货 数量
1mg
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5mg
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10mg
In-stock
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分子式
C16H13F2NO3S2
分子量
369.41
CAS号
158205-05-1
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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