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CP 316311 (Synonyms:5-氯-4-碘-1H-吡咯并[2,3-b]吡啶)
目录号 : KG11509 CAS No. : 175139-41-0 纯度 : 98%
Data Sheet 产品使用指南
CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM. CP 316311 fully antagonizes CRF-stimulated adenylate cyclase activity in rat cortex and at human CRF1 receptors endogenously expressed in IMR32 cells with apparent Ki values of 7.6 and 8.5 nM, respectively. CP 316311 (3.2 mg/kg) inhibits 125I-oCRF binding by >80% in rats. CP 316311 significantly attenuates activation of the hypothalamic-pituitary-adrenal (HPA) axis, with an MED value of 10 mg/kg, p.o. CP 316311 blocks the effects of both the exogenous and endogenous CRF in the CNS. CP 316311 blocks the effects induced by the exogeneous or endogeneous CRF in the brain in rat models.
规格 价格 是否有货 数量
1mg
In-stock
5mg
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10mg
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20mg
In-stock
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分子式
C21H29NO2
分子量
327.46
CAS号
175139-41-0
中文名称
5-氯-4-碘-1H-吡咯并[2,3-b]吡啶
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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