KKL 顾客使用本产品发表的 10 篇科研文献

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC₅₀ of 7.9 nM.

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca influx into cells with IC₅₀s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC₅₀ of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents.

SAR7334 (10 mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).

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