Tubulysin A (TubA)
(Synonyms:N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸)
目录号 : KG10382
CAS No. : 205304-86-5
纯度 : 98%
Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.IC50 value: Target: microtubuleTubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.
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| 分子式 |
C43H65N5O10S
|
| 分子量 |
844.07
|
| CAS号 |
205304-86-5
|
| 中文名称 |
N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|