FG-2216 - CAS:223387-75-5

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FG-2216 (Synonyms:IOX3; YM311)

目录号 : KM7112 CAS No. : 223387-75-5 纯度 : 98%

Data Sheet 产品使用指南

FG-2216 (IOX3) 是一种有效和口服活性的 HIF 脯氨酰羟化酶-2 (PHD2) 抑制剂，IC₅₀ 值为 3.9 nM。FG-2216 在体内诱导促红细胞生成素生成和胎儿血红蛋白的表达。

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2mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC₅₀ of 3.9 nM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo.

体外研究

FG-2216 (50-100 μM; 24 h) stimulates erythropoietin (Epo) secretion by PHD2 inhibition in Hep3B cells.
FG-2216 (3-100 μM; 24 h) stabilizes HIF-1α and HIF-2α in Hep3B cells.

体内研究

FG-2216 (40-60 mg/kg; p.o. twice a week for 150 d) induces erythropoiesis and a small elevation of hemoglobin (HbF) expression, and is well tolerated in rhesus macaques.
FG-2216 (50 mg/kg; p.o. once daily for 4 or 12 d) increases hematocrit, red blood cell counts, and hemoglobin levels in mice.
FG-2216 (40-60 mg/kg; a single p.o) reversibly induces endogenous Epo in rhesus macaques.

Animal Model:	Male rhesus macaques (3-6 years; 4-7 kg) mice are treated with large-volume phlebotomy with iron supplementation
Dosage:	40, 60 mg/kg
Administration:	P.o. (40 mg/kg) twice a week for 6-8 weeks P.o. (60 mg/kg) twice a week for 6-8 weeks P.o. (60 mg/kg) twice a week for 6-8 weeks
Result:	Exhibited reticulocytosis within 1-2 weeks of dosing. Increased total hemoglobin levels at the end of the study duration.

分子式

C₁₂H₉ClN₂O₄

分子量

280.66

CAS号

223387-75-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 31 mg/mL (110.45 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5630 mL	17.8151 mL	35.6303 mL
5 mM	0.7126 mL	3.5630 mL	7.1261 mL
10 mM	0.3563 mL	1.7815 mL	3.5630 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

科研文献

纯度： 98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation