Myristoleic acid - CAS:544-64-9

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Myristoleic acid

目录号 : KM7089 CAS No. : 544-64-9

Data Sheet 产品使用指南

Myristoleic acid 是 Serenoa repens 提取物中的一种细胞毒性成分，可诱导人前列腺细胞的凋亡和坏死。

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10mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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生物活性

Myristoleic acid, a cytotoxic component in the extract from Serenoa repens, induces apoptosis and necrosis in human prostatic LNCaP cells.

体外研究

Myristoleic acid induces both apoptosis (100 μg/mL, 89.5%) and necrosis (100 μg/mL, 81.8%) in LNCaP cells.
Myristoleic acid inhibited RANKL-induced osteoclast formation in vitro, especially, at later stages of differentiation.

Cell Proliferation Assay

Cell Line:	Human prostatic carcinoma LNCaP cells.
Concentration:	0, 50, 100, 150, 200, 250 μg/mL.
Incubation Time:	24 h.
Result:	When LNCaP cells were treated with 130 μg/mL extract or 100 μg/mL myristoleic acid for 24 hr, the proportion of apoptotic cells was 16.5 and 8.8%, and that of necrotic one was 46.8 and 81.8%, respectively.

体内研究

Myristoleic acid (2 mg/kg, IP every 24 h for 4 days) prevents RANKL-induced bone loss and osteoclast formation in mice.

Animal Model:	C57BL/6 mice at 5 weeks.
Dosage:	0.2, 2 mg/kg
Administration:	IP every 24 h for 4 days.
Result:	Co-administration of myristoleic acid suppressed generation of TRAP-positive osteoclasts induced by sRANKL and attenuated the increases in osteoclastic indices of Oc.S/BS, N.Oc/B. Pm and ES/BS in a dose-dependent manner.

分子式

C₁₄H₂₆O₂

分子量

226.36

CAS号

544-64-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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