CV1808 (Synonyms:2-Phenylaminoadenosine)
目录号 : KM7060 CAS No. : 53296-10-9 纯度 : 98%

CV1808 (2-Phenylaminoadenosine) 是一种非选择性 A2 腺苷受体 (A2 AR) 激动剂,对 A2A 和 A3 腺苷受体亚型的 Ki 分别为 76 和 1450 nM。

规格 价格 是否有货 数量
5mg
In-stock

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生物活性

CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.

体外研究

CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM.
In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM.

体内研究

Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles.

Animal Model: Male Sprague-Dawley rat, weighing 370-410 g
Dosage: 0.002, 0.02, 0.2, and 2 μM
Administration: Single afferent arterioles of Sprague-Dawley rats were visualized and superfused with solutions containing CV-1808
Result: Afferent arteriolar diameter increased from 17.0±0.3 to 17.2±0.4, 17.8±0.4, 18.5±0.5, and 19.9±0.7 μM, 17.2±2.4% at concentrations of 0.002, 0.02, 0.2, and 2 μM.
分子式
C16H18N6O4
分子量
358.35
CAS号
53296-10-9
中文名称
2-苯基氨基腺苷
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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