CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively.
体外研究
CV1808 demonstrates an inhibitory effect on anti-IgE-induced activation at 100 μM.
In the presence of Forskolin (1 μM in PC12 cells; 10 μM in Jurkat cells) the EC50 value for CV1808 is 2 μM.
体内研究
Single afferent arterioles of Sprague-Dawley rats are visualized and superfused with solutions containing CV1808 (CV-1808). Superfusion with CV1808 (0.002-2 μM) dilates afferent arterioles.
Animal Model:
Male Sprague-Dawley rat, weighing 370-410 g
Dosage:
0.002, 0.02, 0.2, and 2 μM
Administration:
Single afferent arterioles of Sprague-Dawley rats were visualized and superfused with solutions containing CV-1808
Result:
Afferent arteriolar diameter increased from 17.0±0.3 to 17.2±0.4, 17.8±0.4, 18.5±0.5, and 19.9±0.7 μM, 17.2±2.4% at concentrations of 0.002, 0.02, 0.2, and 2 μM.
分子式
C16H18N6O4
分子量
358.35
CAS号
53296-10-9
中文名称
2-苯基氨基腺苷
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.