Radotinib (Synonyms:4-甲基-N-(3-(4-甲基-1H-咪唑-1-基)-5-(三氟甲基)苯基)-3-((4-(吡嗪-2-基)嘧啶-2-基)氨基)苯甲酰胺;拉多替尼)
目录号 : KCM15781 CAS No. : 926037-48-1 纯度 : ≥98%
Radotinib is a selective second generation tyrosine kinase inhibitor that targets both the wild-type and mutant forms of Bcr-Abl, with an IC value of 30.6 nM in Ba/F3 human chronic myeloid leukemia cells expressing the wild-type form. Radotinib also inhibits platelet-derived growth factor receptors (PDGFRs) α and β with IC values of 75.5 and 130 nM, respectively. Binding of radotinib to Bcr-Abl in vitro inhibits the phosphorylation of the downstream signaling mediator CrkL. In acute myeloid leukemia cells, in vitro treatment with radotinib at doses of 10-100 µM reduces viability, activates the mitochondrial apoptosis pathway, and promotes expression of the differentiation marker CD11b.
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分子式
C27H21F3N8O
分子量
530.5
CAS号
926037-48-1
中文名称
Radotinib(IY-5511)
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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