MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively.
IC50&Target
MMP-2
6.6 μM (IC50)
MMP-13
1.8 μM (IC50)
MMP-1
10 μM (IC50)
MMP-9
13 μM (IC50)
体外研究
MMPI-1154 (1-100 μM) inhibits MMP-2 enzyme isolated from rat heart in vitro, and 100% inhibition appears at the concentraction 100 μM. MMPI-1154 (1 μM) shows significant cardio-cytoprotecion, significantly decreases infarct size in an ex vivo model for acute myocardial infarction.
分子量
445.49
CAS号
1382722-47-5
运输条件
Room temperature in continental US; may vary elsewhere.