JG-98 - CAS:1456551-16-8

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JG-98

目录号 : KM6007 CAS No. : 1456551-16-8 纯度 : 98%

Data Sheet 产品使用指南

JG-98 是一种热休克蛋白 70 (Hsp70) 变构抑制剂，可与 Hsp70 上的保守位点紧密结合，打断 Hsp70-Bag3 相互作用。JG-98 影响癌细胞和肿瘤相关巨噬细胞，显示抗癌活性。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock

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Other Forms of Rapamycin:

Ginkgolide B In-stock
Isoginkgetin In-stock
Ginkgolic acid C17:1 In-stock
Ginkgolic Acid In-stock
Propargyl-PEG4-amine In-stock

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生物活性

JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.

体外研究

JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC₅₀s between ~0.3 and 4 μM.
JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells.
JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27.

Cell Proliferation Assay

Cell Line:	MCF-7, MDA-MB-231, A375, MeWo, HeLa, HT-29, SKOV3, Jurkat, mouse embryonic fibroblasts (MEF), MM1.R, INA6, RPMI-8226, JJN-3, U266, NCI-H929, L363, MM1.S, KMS11, LP-1, AMO-1, OPM1, OPM2 cells
Concentration:	30 nM-30 μM
Incubation Time:	72 hours
Result:	Active against all of the lines tested, and the EC₅₀s were variable (between ~0.3 μM and 4 μM). Normal MEFs and OPM1 and OPM2 were relatively less sensitive.

Western Blot Analysis

Cell Line:	MDA-MB-231 cells
Concentration:	10 μM
Incubation Time:	48 hours
Result:	Incudes apoptotic mediators cleavage of caspase 3 and PARP.

体内研究

JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells.

Animal Model:	6-week-old NCR mice (xenografts of MCF7 and HeLa cells)
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection; on days 0, 2, and 4
Result:	Limited tumor growth, but somewhat less effectively.

分子式

C₂₄H₂₁Cl₂N₃Os₃

分子量

534.54

CAS号

1456551-16-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 5 mg/mL (9.35 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8708 mL	9.3538 mL	18.7077 mL
5 mM	0.3742 mL	1.8708 mL	3.7415 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

纯度： 98%

Data Sheet

产品使用指南

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Other Forms of Rapamycin:

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