Cirazoline hydrochloride (LD 3098 hydrochloride) 是一种强有力的竞争性 α1A 肾上腺素受体 (α1A-AR) 的全激动剂，α1B-AR 和 α1D-AR 的部分激动剂，Ki 值分别为 120 nM， 960 nM 和 660 nM。
| 生物活性 |
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM). |
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| 体外研究 |
Cirazoline hydrochloride (5-10 μM; 24 hours) does not alter GIC survival and counteracted only poorly prazosin‐induced GIC death. Cell Viability Assay
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| 体内研究 |
Cirazoline hydrochloride (drinking water; 40 μM; 9 month) exhibits significantly decreased immobility in the TST and enhances neurogenesis in the mouse.
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| 分子式 |
C13H16N2O.HCl
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| 分子量 |
252.74
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| CAS号 |
40600-13-3
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
H2O : 33.33 mg/mL (131.87 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
纯度： 98%
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