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Diapocynin (Synonyms:1,1'-(6,6'-dihydroxy-5,5'-dimethoxy-1,1'-biphenyl-3,3'-diyl)diethanone)
目录号 : KCM13193 CAS No. : 29799-22-2 纯度 : ≥98%
Data Sheet 产品使用指南
Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin that has anti-inflammatory and antioxidant activities. Diapocynin inhibits NADPH oxidase complex assembly and activation, gp91 mRNA expression, and production of the pro-inflammatory cytokines TNF-α and IL-10 in peripheral blood mononuclear cells (PMBCs). It inhibits production of reactive oxygen species (ROS), calcium-independent isoform of phospholipase A (iPLA) function, and reduces Ca influx through store-operated and stretch-activated channels (SOCs and SACs, respectively) in dystrophic myotubes; all functions in the pathogenic cascade leading to muscular dystrophy. Diapocynin also reverses motor coordination deficits in the LRRK2 mouse model of early Parkinson's disease.
规格 价格 是否有货 数量
1mg
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5mg
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10mg
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25mg
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分子式
C18H18O6
分子量
330.3
CAS号
29799-22-2
中文名称
1,1'-(6,6'-dihydroxy-5,5'-dimethoxy-1,1'-biphenyl-3,3'-diyl)diethanone
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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