Diclofenac amide
(Synonyms:1-(2,6-二氯苯基)-2-吲哚酮;1-(2,6-二氯苯基)-1,3-二氢-2H-吲哚-2-酮;1-(2,6-二氯苯基)羟吲哚;1-(2,6-Dichlorophenyl)oxindole 1-(2,6-二氯苯基)羟吲哚;1-(2,6-二氯苯基)-2-吲哚二酮;1-(2,6-二氯苯基)二氢吲哚-2-酮;双氯芬酸钠杂质A(EP) 标准品;双氯芬酸相关物质A USP标准品;双氯芬酸杂质A;双氯芬酸杂质A EP标准品;新非曲明;吲哚酮;双氯芬酸钠中间体;1-(2,6-二氯苯基)-2-羟基吲哚;1-(2,6-二氯苯基)-2-氧代吲哚啉;醋氯芬酸杂质I;双氯芬酸钠杂质A;双氯芬酸内酰胺;醋氯芬酸EP杂质I;双氯芬酸EP杂质A;吲哚酮(2-吲哚酮,2-氧化吲哚))
目录号 : KCM11627
CAS No. : 15362-40-0
纯度 : ≥98%
Diclofenac amide is a prodrug form of the non-steroidal anti-inflammatory drug (NSAID) diclofenac . It decreases paw thickness in a rat model of carrageenan-induced paw edema when administered at a dose of 100 μmol/kg and decreases acetic acid-induced writhing in mice at 100 μmol/kg. Diclofenac amide has reduced ulcerogenicity in rats compared to diclofenac. It is also a degradation product of diclofenac resulting from photo-transformation or spontaneous cyclization in strongly acidic pH conditions. Diclofenac amide has been used as a synthetic intermediate in the synthesis of compounds with anticancer activity as well as compounds with COX-1, COX-2, and/or 5-lipoxygenase (5-LO) inhibitory activity.
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| 分子式 |
C14H9Cl2NO
|
| 分子量 |
278.1
|
| CAS号 |
15362-40-0
|
| 中文名称 |
1-(2,6-二氯苯基)-2-吲哚酮
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|