GBR 12783 dihydrochloride 是一种特异性，有效且选择性的多巴胺摄取抑制剂，可抑制大鼠和小鼠纹状体突触小体对 [3H] 多巴胺 ([3H]dopamine) 的摄取，IC50 分别为 1.8 nM 和 1.2 nM。GBR 12783 dihydrochloride 还可改善大鼠记忆力并增加海马通路乙酰胆碱的释放。
| 生物活性 |
GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats. |
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| 体内研究 |
GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.
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| 分子式 |
C28H32N2O.2[HCl]
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| 分子量 |
485.49
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| CAS号 |
67469-75-4
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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