KLH45 是有效、选择性的 DDHD2 抑制剂，其 IC50 值为 1.3 nM。
| 生物活性 |
KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM. |
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| 体外研究 |
KLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6. Cell Viability Assay
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| 体内研究 |
KLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2 mice.
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| 分子式 |
C24N4O2F3H25
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| 分子量 |
458.48
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| CAS号 |
1632236-44-2
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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