D-Serine - CAS:312-84-5

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D-Serine (Synonyms:(R-Serine))

目录号 : KM4849 CAS No. : 312-84-5 纯度 : ≥98%

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D-Serine ((R)-Serine) 是一种具有独特的神经递质特性的神经胶质-突触相互作用中涉及的内源性氨基酸，是 NMDA 谷氨酸受体的有效共激动剂。D-Serine 在主要的 NMDAR 依赖性过程中具有主要的调节作用，包括 NMDAR 介导的神经传递，神经毒性，突触可塑性和细胞迁移。

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500mg		In-stock
1g		In-stock
5g		In-stock
10g	询价	In-stock
50g	询价	In-stock

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生物活性

D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration.

体外研究

(R)-Serine is synthesized from L-Ser by serine racemase (SR) and degraded by D-amino acid oxidase (DAAO) and SR. Distribution of D-Ser and NMDAR as determined by chemical measurement and immunohistochemistry supports D-Ser as an endogenous coagonist acting on the glycine modulatory site of the NR1 subunits of the NMDAR.

体内研究

(R)-Serine (10 g/L; p.o.; throughout 8 weeks) regulates HFD induced weight gain.

Animal Model:	Four week old male C57Bl/6 mice
Dosage:	10 g/L
Administration:	Oral administration (drinking water supplemented with 10 g/l D-serine); throughout 8 weeks
Result:	Showed strongly reduced weight gain during the first week of supplementation with paralleled weight gain to HFD fed mice, but no catch up thereafter.

分子式

C₃H₇NO₃

分子量

105.09

CAS号

312-84-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : ≥ 50 mg/mL (475.78 mM)

Methanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C)(insoluble)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	9.5157 mL	47.5783 mL	95.1565 mL
5 mM	1.9031 mL	9.5157 mL	19.0313 mL
10 mM	0.9516 mL	4.7578 mL	9.5157 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

纯度： ≥98%

Data Sheet

产品使用指南

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