致电 400-881-9290
登录/ 注册
0 我的购物车
您当前的位置：
  1. 首页
  2. Signal path
  3. PI3K/Akt/mTOR | PI3K/Akt/mTOR 信号通路
  4. PI3K
SRX3207
目录号 : KM4662 CAS No. : 2254693-15-5 纯度 : 98%
Data Sheet 产品使用指南

SRX3207 是具有口服活性的、首创的 Syk/PI3K 双抑制剂，其对 Syk 和 PI3Kα 的 IC50 值分别为 10.7 nM 和 861 nM。SRX3207 缓解抗肿瘤免疫抑制。

规格 价格 是否有货 数量
5mg
In-stock
10mg
In-stock
25mg
In-stock
50mg
In-stock
100mg
In-stock
200mg 询价 In-stock
500mg 询价 In-stock
加入购物车 大包装询价

Other Forms of Rapamycin:

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。
生物活性

SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression.

体外研究

SRX3207 (10 μmol/L) is able to block p-AKT at concentration.
SRX3207 has sufficient solubility in water (43 μmol/L).
体内研究

SRX3207 (10 mg/kg, orally) increases antitumor immune response.

Animal Model: LLC or B16 or B16-OVA or CT26 (1 × 10) cells were injected subcutaneously into syngeneic mice.
Dosage: 10 mg/kg.
Administration: Orally, starting from day 10 when tumors reached 100 mm3 until tumors were harvested on day 21.
Result: Blocked phosphorylation of Syk at 348 site and Y525/526 site.
Blocked immunosuppressive MΦ polarization.
Blocked tumor growth and increased survival effectively.
分子式
C29H29N7O3S
分子量
555.65
CAS号
2254693-15-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 5 mg/mL (9.00 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7997 mL 8.9985 mL 17.9969 mL
5 mM 0.3599 mL 1.7997 mL 3.5994 mL
10 mM --- --- ---
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
暂无相关参考文献
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
重置 计算
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
重置 计算
联系我们
400-881-9290

technical-service@kklmed.com

terminal-order@kklmed.com

terminal-inspection@kklmed.com

dealer-order@kklmed.com

 10338 stony run ln，ste121，ashland，va，23005，USA
KKL MED 小分子
KKL MED

关注我们

获得KKL MED 最新资讯

Copyright © 2013-2022 KKL Med Inc. All Rights Reserved. 粤ICP备2022038512号-1
首页 分类 购物车 会员