SUVN-911 - CAS:2414674-71-6

您当前的位置：

SUVN-911

目录号 : KM4656 CAS No. : 2414674-71-6 纯度 : 98%

Data Sheet 产品使用指南

SUVN-911 是一种高效、选择性的，有大脑通透性和口服生物活性的神经元烟碱乙酰胆碱 α4β2 受体 (α4β2 receptor) 拮抗剂，K_i 值为 1.5 nM。SUVN-911 具有抗抑郁作用。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

查看所有商品（1）

加入购物车大包装询价

Other Forms of Rapamycin:

Ginkgolide J In-stock
Ginkgolide K In-stock
THK-5470 In-stock
NH-3 In-stock
Velufenacin In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a K_i of 1.5 nM. SUVN-911 has antidepressant activity.

体外研究

SUVN-911 displays high selectivity for α4β2 over α3β4 nAChR.
SUVN-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors and prostaglandins.

体内研究

SUVN-911 is devoid of cardiovascular and gastrointestinal side effects.
SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects.
SUVN-911 shows metabolic stability in rats.
SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats.

Animal Model:	Male Wistar rats (180-230 g)
Dosage:	1 mg/kg, 3 mg/kg, 10.0 mg/kg
Administration:	Oral administration, daily, for 3 days
Result:	Showed antidepressant like activity with no signs of tachyphylaxis.

Animal Model:	Male Wistar rats (225 ± 25 g)
Dosage:	3 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral administration
Result:	AUC=3507 ng*h/mL, T_1/2=3.34 hours.

分子式

C₁₁H₁₄Cl₂N₂O

分子量

261.15

CAS号

2414674-71-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 125 mg/mL (478.65 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8292 mL	19.1461 mL	38.2922 mL
5 mM	0.7658 mL	3.8292 mL	7.6584 mL
10 mM	0.3829 mL	1.9146 mL	3.8292 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

纯度： 98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation