PEAQX tetrasodium hydrate

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目录号 : KM4621 纯度 : ≥98%

Data Sheet 产品使用指南

PEAQX (NVP-AAM077) tetrasodium hydrate 是有效的、选择性的、口服有效的 NMDA 拮抗剂，其对 hNMDAR 1A 和 hNMDAR 2A 的 IC₅₀ 值分别为 270 nM 和 29600 nM。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg		In-stock
100mg	询价	In-stock
200mg	询价	In-stock

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生物活性

PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC₅₀ values of 270 nM and 29600 nM for hNMDAR 1A and hNMDAR 2A, respectively.

体外研究

PEAQX (3 µM) produces similar caspase-3 activation, while NVP-AAM007 is approximately three-fold more potent.

体内研究

PEAQX (10-40 mg/kg) dose-dependently increased cortical caspase-3 activity following sub-chronic administration.
PEAQX (10 and 20 mg/kg) shows enhanced locomotor activity in response to PCP challenge (4 mg/kg on PN28-35) compared to saline pretreatment (F_{3, 73}=4.99).
PEAQX (10 mg/kg, ip) antagonizes the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment.

Animal Model:	Timed, day 14 pregnant female Sprague-Dawley rats.
Dosage:	10, 20 or 40 mg/kg.
Administration:	S.C.
Result:	Showed a sensitized locomotor response to PCP challenge on PN28-35.

Animal Model:	Timed, day 14 pregnant female Sprague-Dawley rats.
Dosage:	4 mg/kg.
Administration:	I.P.
Result:	Did not significantly increase locomotor activity in rats treated sub-chronically with PEAQX on PN7, 9 and 11.

Animal Model:	11-week old C57BL/6 mice.
Dosage:	10 mg/kg.
Administration:	IP.
Result:	Reversed the effect of PRE084 (F_3,78 = 10.446, p<0.01).

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 25.5 mg/mL (45.52 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.7852 mL	8.9262 mL	17.8524 mL
5 mM	0.3570 mL	1.7852 mL	3.5705 mL
10 mM	0.1785 mL	0.8926 mL	1.7852 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

纯度： ≥98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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KKL 顾客使用本产品发表的 4 篇科研文献

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