cis-Urocanic acid - CAS:7699-35-6

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cis-Urocanic acid (Synonyms:顺式-尿刊酸; (Z-Urocanic acid; cis-UCA))

目录号 : KM4483 CAS No. : 7699-35-6 纯度 : 98%

Data Sheet 产品使用指南

cis-Urocanic acid 是一种 5-HT2A 受体激动剂。cis-Urocanic acid 以较高亲和力与 5-HT 受体结合，K_d 为 4.6 nM。cis-Urocanic acid 是一种免疫调节剂，通过与 5-HT2A 受体结合而诱导免疫抑制。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (K_d=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.

体外研究

Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic.

Cell Viability Assay

Cell Line:	Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs)
Concentration:	10, 100, 1,000, and 5,000 μg/mL
Incubation Time:	24, 48, or 72 hours
Result:	Treatment with 100 μg/mL completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells were observed with 100 μg/mL in both cell types.

分子式

C₆H₆N₂O₂

分子量

138.12

CAS号

7699-35-6

中文名称

顺式-尿刊酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL (362.00 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	7.2401 mL	36.2004 mL	72.4008 mL
5 mM	1.4480 mL	7.2401 mL	14.4802 mL
10 mM	0.7240 mL	3.6200 mL	7.2401 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

纯度： 98%

Data Sheet

产品使用指南

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