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PI-828
目录号 : KM4421 CAS No. : 942289-87-4 纯度 : ≥98%
Data Sheet 产品使用指南

PI-828 是一种双重 PI3K 和 casein kinase 2 (CK2) 抑制剂，抑制 p110α，CK2 和 CK2α2，IC50 分别为 173 nM，149 nM 和 1127 nM。

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生物活性

PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.

体外研究

PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells.
PI-828 (0.78-3.12 µM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis.

Cell Viability Assay

Cell Line: 4T1 breast cancer cells and 4306 ovarian cancer cells
Concentration: 0.01, 0.1, 1, 10 and 100 μM
Incubation Time:
Result: Exhibited cytotoxic effect.

Apoptosis Analysis

Cell Line: Human embryonic carcinoma NCCIT cells
Concentration: 0.78, 1.56, 3.12, 6.25, 12.5 μM
Incubation Time: 48 hours
Result: Concentrations of ranging from 0.78 to 3.12 µM decreased caspase 3 activation; higher concentrations caused apoptosis.
分子式
C19H18N2O3
分子量
322.36
CAS号
942289-87-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
科研文献
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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