PHA 568487 - CAS:527680-57-5

您当前的位置：

PHA 568487

目录号 : KM3513 CAS No. : 527680-57-5 纯度 : 98%

Data Sheet 产品使用指南

PHA 568487 是 α-7 烟碱乙酰胆碱受体 (α-7 nAchR) 的选择性激动剂。PHA 568487 可减少神经炎症和氧化应激。PHA-568487 可快速透过血脑屏障。

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
50mg		In-stock
100mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

Kgp-IN-1 hydrochloride In-stock
Ginkgolide A In-stock
Ginkgetin In-stock
VKGILS-NH2 In-stock
7,3',4'-Tri-O-methylluteolin In-stock

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

PHA 568487 a selective agonist of alpha-7 nicotinic acetylcholine receptor (α-7 nAchR).PHA 568487 reduces neuroinflammation and oxidative stress. PHA-568487 has rapid brain penetration.

体外研究

PHA 568487 increases anti-oxidant gene expression and decreases oxidative stress and phosphorylation of NF-κb p65. Methyllycaconitine (MLA) has the opposite effects.
PHA increases anti-oxidant genes and NADPH oxidase expression associated with decreased phosphorylation of NF-kB p65 in microglia/macrophages.

体内研究

PHA 568487 attenuates neuronal injury and behavioral dysfunction in mice with ischemic stroke only and ischemic stroke plus tibia fracture.
PHA 568487 (1.25 mg/kg; i.p.; treated daily)-treated ischemic rats shows a significant reduction of the cerebral infarct volumes and an improvement of the neurologic outcome.

Animal Model:	C57BL/6J male mice (10-12 weeks old)
Dosage:	PHA 568487 (PHA; 0.4 and 0.8 mg/kg); Methyllycaconitine (MLA; 4 and 6 mg/kg)
Administration:	Injected intraperitoneally once on day 1, or twice on days 1 and 2, after pMCAO
Result:	Injection of PHA (0.8 mg/kg) and MLA (6 mg/kg) on days 1 and 2 after pMCAO yielded the best effect on infarct volume and behavior tests.

Animal Model:	Adult male Sprague-Dawley rats (297 6±8.3 g)
Dosage:	1.25 mg/kg
Administration:	I.p.;0.1 mL; treated daily
Result:	Showed a significant reduction of the cerebral infarct volumes and an improvement of the neurologic outcome.

分子式

C₂₀H₂₄N₂O₇

分子量

404.41

CAS号

527680-57-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度： 98%

Data Sheet

产品使用指南

暂无相关参考文献

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

联系我们

400-881-9290
technical-service@kklmed.com

terminal-order@kklmed.com

terminal-inspection@kklmed.com

dealer-order@kklmed.com
10338 stony run ln，ste121，ashland，va，23005，USA

客户服务

快速询价订购信息售后服务退货和退款销售通用条款 Literature Award

KKL MED 小分子

KKL MED

关注我们

获得KKL MED 最新资讯

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation