PHPS1 sodium - KKL Med Inc.

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PHPS1 sodium

目录号 : KM3060 纯度 : ≥98%

Data Sheet 产品使用指南

PHPS1 sodium 是一种有效的选择性 Shp2 抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 K_i 值分别为 0.73，5.8，10.7，5.8 和 0.47 μM。

规格	价格	是否有货
5mg		In-stock
10mg	询价	In-stock
50mg	询价	In-stock

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生物活性

PHPS1 sodium is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively.

体外研究

PHPS1 (30 μM; 6 days) inhibits proliferation of human tumor cells.
PHPS1 (5-20 μM; 5-360 minutes) inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner.

Cell Viability Assay

Cell Line:	Human cancer cell lines MDA-MB-435, HCT-116 (colon carcinoma), HCT-15 (colon carcinoma), PC-3 (prostate carcinoma), HT-29 (colon carcinoma), NCI-H661 (lung carcinoma), and Caki-1 (kidney carcinoma)
Concentration:	30 μM
Incubation Time:	6 days
Result:	Resulted in a reduction in cell number of between 0% (Caki-1) to 74% (HT-29).

Western Blot Analysis

Cell Line:	Madin-Darby canine kidney (MDCK) cells
Concentration:	5, 10, 20 μM
Incubation Time:	5, 15, 60, 120, 360 minutes
Result:	Inhibited HGF/SF (1 unit/mL)-induced phosphorylation and thus activation of Erk1/2 over a time period of 15 min to 6 h. In contrast, transient phosphorylation of Erk1/2 after 5 min was not affected. Exhibited no effect on HGF/SF-induced activation of PI3K/Akt or Stat3.

体内研究

PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr mice less susceptible to atherosclerosis development.

Animal Model:	Ldlr (005061) mice
Dosage:	3 mg/kg
Administration:	Intraperitoneal (i.p.) injection; every day during the last week on the high-fat diet.
Result:	Revealed a significant decrease in atherosclerotic plaque size in the aorta compared with the other two groups.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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The molarity calculator equation

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