Soyasaponin II 是具有抗病毒活性的皂苷。Soyasaponin II 抑制 HSV-1，HCMV，流感病毒和 HIV-1 的复制。Soyasaponin II 对 HSV-1 复制显示出有效的抑制作用。Soyasaponin II 作为 YB-1 磷酸化和 NLRP3 炎性小体引发的抑制剂，可保护小鼠免受 LPS/GalN 诱导的急性肝衰竭。
| 生物活性 |
Soyasaponin II is a saponin with antiviral activity. Soyasaponin II inhibits the replication of HSV-1, HCMV, influenza virus, and HIV-1. Soyasaponin II shows potent inhibition on HSV-1 replication. Soyasaponin II serves as a inhibitor for YB-1 phosphorylation and NLRP3 inflammasome priming and could protect mice against LPS/GalN induced acute liver failure. |
|---|---|
| 体外研究 |
Soyasaponin II inhibits the replication of HSV-1 (IC50=54μM), HCMV (104μM), influenza virus (88μM), and HIV-1 (112 μM). |
| 体内研究 |
Soyasaponin II (5 mg/kg; p.o.; once a day for three consecutive days) ameliorates canonical NLRP3 inflammasome-associated innate immune response.
|
| 分子式 |
C47H76O17
|
| 分子量 |
913.10
|
| CAS号 |
55319-36-3
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
纯度： 98%
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