p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects.
IC50&Target
5-HT1A Receptor
体外研究
p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity.
体内研究
p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze.
Animal Model:
Adult male Swiss Webster mice (aged 8-9 weeks)
Dosage:
0.5, 1.5, 4.5 mg/kg
Administration:
i.p.
Result:
Produced a significant and dose-related anxiolytic profile on both conventional (open arm avoidance) and ethological (risk assessment) measures.
分子式
C25H27N4O2I.HCl
分子量
578.87
CAS号
220643-77-6
运输条件
Room temperature in continental US; may vary elsewhere.