Norgestrel - CAS:6533-00-2

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Norgestrel (Synonyms:炔诺孕酮)

目录号 : KM20235 CAS No. : 6533-00-2 纯度 : 98%

Data Sheet 产品使用指南

Norgestrel 是孕酮的合成类似物，是口服避孕药中常见的化合物，也是一种强大的神经保护性抗氧化剂，可防止光诱导的感光细胞中的 ROS 的生成以及细胞死亡。

规格	价格	是否有货
50mg		In-stock
100mg		In-stock
250mg		In-stock
500mg	询价	In-stock
1g	询价	In-stock

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生物活性

Norgestrel is a synthetic analog of progesterone, a compound commonly found in oral contraceptive pill, and a powerful neuroprotective antioxidant, preventing light-induced ROS in photoreceptor cells, and cell death.

体外研究

Norgestrel (20 µM; 24 hours; 661W cells) treatment significantly increases cellular viability after serum deprivation and so it is demonstrated that Norgestrel is neuroprotective to stressed 661W cells.
Norgestrel (20 µM; 24 hours; 661W cells) treatment decreases apoptotic induced cleavage of PARP and caspase-3.
Norgestrel (20 µM; 6 hours; 661W cells) treatment bFGF is results in a significant upregulation of bFGF mRNA in photoreceptor cells.

Cell Viability Assay

Cell Line:	661W cells
Concentration:	20 µM
Incubation Time:	24 hours
Result:	Significantly increased cellular viability after serum deprivation.

Western Blot Analysis

Cell Line:	661W cells
Concentration:	20 µM
Incubation Time:	24 hours
Result:	Decreased apoptotic induced cleavage of PARP and caspase-3.

RT-PCR

Cell Line:	661W cells
Concentration:	20 µM
Incubation Time:	6 hours
Result:	A significant upregulation of bFGF mRNA over 1 hour.

体内研究

Norgestrel (100 mg/kg; intraperitoneal injection; for 6, 24 or 48 hours; Balb/c mice) treatment can prevent light-induced ROS in photoreceptor cells, and subsequent cell death. Norgestrel acts via post-translational modulation of the major antioxidant transcription factor Nrf2; bringing about its phosphorylation, subsequent nuclear translocation, and increases levels of its effector protein superoxide dismutase 2 (SOD₂).

Animal Model:	Balb/c mice are born into and maintained in dim cyclic light
Dosage:	100 mg/kg;
Administration:	Intraperitoneal injection; for 6, 24 or 48 hours
Result:	Increased expression and activation of Nrf2 via phosphorylation on serine 40, increased expression of its target antioxidant superoxide dismutase 2 (SOD₂), and reduced mitochondrial oxidative stress.

分子式

C₂₁H₂₈O₂

分子量

312.45

CAS号

6533-00-2

中文名称

炔诺孕酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 125 mg/mL (400.06 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.2005 mL	16.0026 mL	32.0051 mL
5 mM	0.6401 mL	3.2005 mL	6.4010 mL
10 mM	0.3201 mL	1.6003 mL	3.2005 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 6.25 mg/mL (20.00 mM); Clear solution

此方案可获得 ≥ 6.25 mg/mL (20.00 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 62.5 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

临床试验

纯度： 98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 0 篇科研文献

The molarity calculator equation

The dilution calculator equation