Okadaic acid 是一种海洋毒素，是蛋白质磷酸酶 (PP) 的抑制剂，包括 PP1 (IC50=15-50 nM)、PP2A (IC50=0.1-0.3 nM)、PP3 (IC50=3.7-4 nM)、PP4 (IC50=0.1 nM) 和 PP5 (IC50=3.5 nM)，其中对 PP2A 的亲和力最显著。Okadaic acid 通过抑制 PP 增加了多种蛋白的磷酸化，并具有肿瘤启动子的作用。
| 生物活性 |
Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM). Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. |
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| 体外研究 |
Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells. Cell Proliferation Assay
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| 分子式 |
C44H68O13
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| 分子量 |
805.00
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| CAS号 |
78111-17-8
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| 中文名称 |
冈田酸
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Solution, -20°C, 2 years |
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| 科研文献 |
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