Girinimbine - CAS:23095-44-5

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Girinimbine (Synonyms:Girinimbin)

目录号 : KM19868 CAS No. : 23095-44-5 纯度 : 98%

Data Sheet 产品使用指南

Girinimbine (Girinimbin) 是一种咔唑类生物碱，具有多种生物学作用。Girinimbine 可诱导细胞凋亡 (apoptosis)，具有抗锥虫、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock

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生物活性

Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities.

体外研究

Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC₅₀ values of 61 µM, 56 µM, and 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells.
Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells. HepG2 cells.
Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest.
Girinimbine shows a potent antitrypanosomal activitywith an IC₅₀ value of 10.16 µg/mL.

Cell Viability Assay

Cell Line:	HepG2 cells
Concentration:	1 µM, 10 µM, 50 µM, 100 µM, 200 µM
Incubation Time:	24 h, 48 h and 72 h
Result:	Inhibited the proliferation of HepG2 cells in vitro in a dose- and time-dependent manner.

Apoptosis Analysis

Cell Line:	HepG2 cells
Concentration:	56 µM
Incubation Time:	24 h, 48 h
Result:	Showed typical morphological features of apoptosis.

Cell Cycle Analysis

Cell Line:	HepG2 cells
Concentration:	56 µM
Incubation Time:	12 h, 24 h, 48 h
Result:	Induced G0/G1-phase arrest in HepG2 cells.

体内研究

Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid.
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos.

Animal Model:	Male ICR mice (25-35 g) treated with carrageenan
Dosage:	10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration:	Orally gavage; once
Result:	Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.

分子式

C₁₈H₁₇NO

分子量

263.33

CAS号

23095-44-5

中文名称

吉九里香碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度： 98%

Data Sheet

产品使用指南

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