Strictosidinic acid 是一种具有口服活性的，从 Psychotria myriantha 叶中分离的糖苷吲哚单萜生物碱，抑制 5-HT 生物合成的前体酶并降低 5-HT 含量。Strictosidinic acid 在小鼠中具有外周缓解疼痛和解热活性。
| 生物活性 |
Strictosidinic acid, an orally active glycoside indole monoterpene alkaloid isolated from Psychotria myriantha leaves, inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels. Strictosidinic acid has peripheral analgesic and antipyretic activities in mice. |
|---|---|
| 体内研究 |
Strictosidinic acid (20 μg/μl; intra-hippocampal injection) causes a significance of 83.5% reduction in 5-HT levels. Strictosidinic acid (10 mg/kg; i.p.) causes a 63.4% reduction in 5-HT levels and a 67.4% reduction in DOPAC values in male Wistar rats, weighing 200-250 g.
|
| 分子式 |
C26H32N2O9
|
| 分子量 |
516.54
|
| CAS号 |
150148-81-5
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
纯度： 98%
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