Bisoprolol hemifumarate - CAS:104344-23-2

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Bisoprolol hemifumarate (Synonyms:富马酸比索洛尔)

目录号 : KM19275 CAS No. : 104344-23-2 纯度 : 98%

Data Sheet 产品使用指南

Bisoprolol hemifumarate 是 β1 肾上腺素受体 (β1 adrenergic receptor) 阻断剂。

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100mg		In-stock
200mg		In-stock
500mg		In-stock
1g	询价	In-stock
5g	询价	In-stock

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生物活性

Bisoprolol hemifumarate is a selective type β1 adrenergic receptor blocker.

体内研究

Bisoprolol hemifumarate, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, Bisoprolol hemifumarate was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only Bisoprolol hemifumarate.
Bisoprolol hemifumarate administration resulted in a significant reduction in HR reaching 60.3 +/- 1.4 bpm at VT of 500 mL (compared to 70.5 bpm with placebo). Changes in HP were also significant with an increase in HP reaching 1004.5 msec at this controlled VT (compared to 860.3 msec with placebo).
Toxicity: Oral, mouse: LD50=100 mg/kg; Skin, rabbit: LD50=200 mg/kg; Skin, rat: LD50=500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat.

分子式

C₄₀H₆₆N₂O₁₂

分子量

766.96

CAS号

104344-23-2

中文名称

富马酸比索洛尔

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 50 mg/mL (65.19 mM)

H₂O : 20 mg/mL (26.08 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3038 mL	6.5192 mL	13.0385 mL
5 mM	0.2608 mL	1.3038 mL	2.6077 mL
10 mM	0.1304 mL	0.6519 mL	1.3038 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (130.38 mM); Clear solution; Need ultrasonic

科研文献

纯度： 98%

Data Sheet

产品使用指南

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