rel-α-Vitamin E - CAS:2074-53-5

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rel-α-Vitamin E (Synonyms:rel-(+-α-Tocopherol; rel-D-α-Tocopherol))

目录号 : KM18866 CAS No. : 2074-53-5 纯度 : ≥98%

Data Sheet 产品使用指南

rel-α-Vitamin E (rel-(+)-α-Tocopherol) 是一种具有抗氧化特性的维生素，也是一种混合物。

规格	价格	是否有货
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

rel-α-Vitamin E (rel-(+)-α-Tocopherol) is a vitamin with antioxidant properties and also a mixture.

体外研究

Vitamin E is a lipid-soluble, chain-breaking type of antioxidant present in human blood. Vitamin E works as a free radical scavenger and has the primary function of destroying peroxyl radicals. Thus, it protects long-chain polyunsaturated fatty acids (e.g., cell membranes or low-density lipoprotein cholesterol) from oxidation or destruction. Its association with vitamin C is of great pathophysiological importance, because inhibition of lipid peroxidation by α-tocopherol occurs through its conversion into an oxidized α-tocopheroxyl radical, which in turn is regenerated to α-tocopherol through reduction by redox-active reagents.
α-Tocopherol can inhibit the recruitment of lymphocytes and eosinophils.

体内研究

In order to longitudinally relate vitamin E status, evaluated by means of α- and γ-tocopherol measured in erythrocytes membranes, to inflammatory state and oxidative stress by means of total antioxidant capacity of plasma and lipid peroxidation biomarkers, and to assess its association to hard long-term outcomes (e.g., overall and cause-specific graft and recipient loss), and to be able to likewise account for liver, lung, and heart transplant recipients.

分子式

C₂₉H₅₀O₂

分子量

430.71

CAS号

2074-53-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

Ethanol : 50 mg/mL (116.09 mM; Need ultrasonic)

DMSO : 16.11 mg/mL (37.40 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3217 mL	11.6087 mL	23.2175 mL
5 mM	0.4643 mL	2.3217 mL	4.6435 mL
10 mM	0.2322 mL	1.1609 mL	2.3217 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 1.61 mg/mL (3.74 mM); Clear solution

此方案可获得 ≥ 1.61 mg/mL (3.74 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 16.1 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 1.61 mg/mL (3.74 mM); Clear solution

此方案可获得 ≥ 1.61 mg/mL (3.74 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 16.1 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。