Cimifugin (Cimitin) is a bioactive component of Saposhnikovia divaricata, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions.
体外研究
The effect of Cimifugin (Cimitin) on TSLP decreases significantly when expression of CLDN1 is interfered with siRNA and this implied Cimifugin inhibits initiative cytokines through restoring TJs.
体内研究
Cimifugin (Cimitin; 12.5 or 50 mg/kg/day; intragastrically; 2 days) significantly inhibits TSLP and IL-33 in the initial stage of Mice are sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. Simultaneously, Cimifugin reduces the separated gap among the epithelial cells and increased the expression of TJs.
分子式
C16H18O6
分子量
306.31
CAS号
37921-38-3
中文名称
升麻素
运输条件
Room temperature in continental US; may vary elsewhere.