Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABA-B receptor (GABABR) agonist. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research.
体内研究
Baclofen, a lipophilic analog of gamma-aminobutyric acid, is clinically used to control spasticity. Baclofen pretreatment (3 mg/kg) not only prolonged the time taken for animals to reach a core body temperature of 40 degrees C (P<0.001), but also reduced the percentage of rats attaining a core body temperature of 40 degrees C.
分子式
C10H12ClNO2
分子量
213.66
CAS号
1134-47-0
中文名称
巴氯芬;氯苯氨丁酸
运输条件
Room temperature in continental US; may vary elsewhere.