Manganese(salen) chloride - CAS:53177-12-1

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Manganese(salen) chloride (Synonyms:EUK-8)

目录号 : KM18337 CAS No. : 53177-12-1 纯度 : ≥95%

Data Sheet 产品使用指南

Manganese(salen) chloride (EUK-8)，一种超氧化物歧化酶和过氧化氢酶模拟物，是具有氧自由基清除性能的抗氧化剂。Manganese(salen) chloride 可减轻内毒素血症猪的急性肺损伤。

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10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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生物活性

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.

体外研究

Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation.

体内研究

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.

Animal Model:	Wild-type (WT) and harlequin (Hq) B6CBA male and female mice
Dosage:	25 mg/kg/day
Administration:	I.p. 3 times a week for 4 weeks
Result:	Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.

分子式

C₁₆H₁₄ClMnN₂O₂

分子量

356.69

CAS号

53177-12-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 8.33 mg/mL (23.35 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8036 mL	14.0178 mL	28.0355 mL
5 mM	0.5607 mL	2.8036 mL	5.6071 mL
10 mM	0.2804 mL	1.4018 mL	2.8036 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%

Data Sheet

产品使用指南

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